Endocrine Abstracts

Augmented pervasiveness of type 2 diabetes mellitus and obesity has amplified the medical necessitate for new agents to treat these disease states. Both type 2 diabetes and obesity are connected to the resistance to the hormones insulin and leptin. Protein tyrosine phosphatase 1B (PTP1B) has been shown to function as negative regulator of insulin signalling as well as leptin signal transduction. At present there are copious compounds synthesized as PTP1B inhibitors. The develo...